Sheffield United host Man City at Bramall Lane in the Premier League. The Blades are winless in their last nine league games, the longest ongoing run of the current PL sides.
Reigning Grand Slam champions Wales host Scotland in the final round of the Six Nations.
Nearly eight months on from their last game, England complete their disrupted Six Nations campaign against Italy at the Stadio Olimpico in Rome.
Liverpool welcome West Ham United to Anfield in Saturday evening action from the Premier League. The Reds will go top of the table with a win. W
Live coverage of the final and decisive match of the 2020 Six Nations, with the result at the Stade de France dictating who wins the Championship.
Kilmarnock take on Rangers at Rugby Park in Sunday lunchtime action from the Scottish Premiership. Steven Gerrard's side are looking to continue a fine unbeaten start to the season.
Newcastle United welcome Carlo Ancelotti's Everton to St James' Park in the Premier League. A Dominic Calvert-Lewin brace led Everton to a 2-1 win here last season.
A big clash from the Premier League as Manchester United welcome Arsenal to Old Trafford. The sides shared the spoils in a 1-1 draw here last season.
Two of the Premier League's early high-flyers clash as Leeds United take on Leicester City at Elland Road in Monday Night Football.